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15. TYPICAL FORMS OF PATHOLOGY OF THE RED BLOOD CELL SYSTEM. ANEMIA. ERYTHROCYTOSIS

Questions to prepare for classes and examination

 Definition of anemia and its classification.

 Anemias of blood loss: types, causes, hematological signs.

 Hemolytic anemias: types, common causes, manifestations, hematologi-cal signs.

 Hereditary spherocytosis: pathogenesis, manifestations, hematological signs.

 Sickle cell disease: pathogenesis, manifestations, hematological signs.

 Thalassemia syndromes: types, pathogenesis, manifestations, hematologi-cal signs.

 Megaloblastic anemias: types, causes, pathogenesis, manifestations, hematological signs.

 Iron deficiency anemia: causes, pathogenesis, manifestations, hematologi-cal signs.

 Aplastic anemia: causes and pathogenesis, hematological signs.

 Erythrocytosis: causes and mechanisms.

N 66

A 5-year-old female patient Z. was admitted to hospital with a preliminary diagnosis of pneumonia. On admission: the skin and conjunctiva appeared jaundiced, the body temperature was 39 °C, the spleen and liver were enlarged, the urine was dark; the patient complained of an acute pain in the back, in the right anterior abdomen, in the leg's muscles. An X-ray investigation of the chest revealed signs of bronchopneumonia. Blood tests showed the following: Hb 69 g/L, erythrocytes 2.3Ч1012/L, MCH (mean corpuscular hemoglobin) 30 pg; the presence of poikilocytosis and anisocytosis of erythrocytes. The urine test revealed the presence of Hb. During electrophoretic investigation of the patient's Hb the HbS type was found in addition to HbA.

Questions

 What forms of pathology are observed in the given patient? Substantiate your answer.

 Explain the cause-effect and chronologic relationship between the observed forms of pathology.

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